1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline
Fmoc-Pro-Pro-OH
CAS: 129223-22-9
Molecular Formula: C25H26N2O5
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline - Names and Identifiers
| Name | Fmoc-Pro-Pro-OH |
| Synonyms | Fmoc-Pro-Pro-OH FMOC-PRO-PRO-OH Fmoc-L-Pro-L-Pro-OH Fmoc-Prolinyl-proline Fmoc-ProlylProline-OH Fmoc-Prolinyl-proline (S,S) 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline L-Proline, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl- (S)-1-((S)-1-(((9H-Fluoren-9-yl)Methoxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid (S)-1-((S)-1-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid |
| CAS | 129223-22-9 |
| InChI | InChI=1/C25H26N2O5/c28-23(26-13-6-12-22(26)24(29)30)21-11-5-14-27(21)25(31)32-15-20-18-9-3-1-7-16(18)17-8-2-4-10-19(17)20/h1-4,7-10,20-22H,5-6,11-15H2,(H,29,30)/t21-,22-/m0/s1 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline - Physico-chemical Properties
| Molecular Formula | C25H26N2O5 |
| Molar Mass | 434.48 |
| Density | 1.353±0.06 g/cm3(Predicted) |
| Boling Point | 677.7±55.0 °C(Predicted) |
| Flash Point | 363.679°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| pKa | 3.51±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.638 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline - Introduction
N-fluorenylmethoxycarbonyl-prolyl-proline, abbreviated as Fmoc-prolyl-proline, is an organic compound.
Nature:
Fmoc-prolyl-proline is a white solid with a strong volatile odor. It is stable at room temperature and can be stored for a long time in a dry state. It is soluble in organic solvents and only slightly soluble in water.
Use:
Fmoc-prolyl-proline is mainly used as a protecting group in solid phase synthesis (peptide synthesis). It can temporarily protect the amino group as the Fmoc group during the synthesis of the polypeptide to prevent the reaction of other parts, and then remove the Fmoc group by deprotection reaction to restore the activity of the amino group, so as to achieve the extension of the polypeptide chain.
Preparation Method:
Fmoc-prolyl-proline can be produced by esterification of proline with Fmoc-OSu (hydroxysuccinimide). The specific preparation method can refer to the organic chemical synthesis literature.
Safety Information:
The use of Fmoc-prolyl-proline should be subject to laboratory safety procedures. Avoid inhalation or contact with skin during use. Wear appropriate protective gloves, glasses and protective clothing. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical attention if necessary. At the same time, please store and handle the compound properly, avoid contact with flammable or oxidizing agent.
Nature:
Fmoc-prolyl-proline is a white solid with a strong volatile odor. It is stable at room temperature and can be stored for a long time in a dry state. It is soluble in organic solvents and only slightly soluble in water.
Use:
Fmoc-prolyl-proline is mainly used as a protecting group in solid phase synthesis (peptide synthesis). It can temporarily protect the amino group as the Fmoc group during the synthesis of the polypeptide to prevent the reaction of other parts, and then remove the Fmoc group by deprotection reaction to restore the activity of the amino group, so as to achieve the extension of the polypeptide chain.
Preparation Method:
Fmoc-prolyl-proline can be produced by esterification of proline with Fmoc-OSu (hydroxysuccinimide). The specific preparation method can refer to the organic chemical synthesis literature.
Safety Information:
The use of Fmoc-prolyl-proline should be subject to laboratory safety procedures. Avoid inhalation or contact with skin during use. Wear appropriate protective gloves, glasses and protective clothing. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical attention if necessary. At the same time, please store and handle the compound properly, avoid contact with flammable or oxidizing agent.
Last Update：2024-04-09 02:00:41
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CAS: 129223-22-9
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CAS: 129223-22-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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